FORMULATION OF SARS-COV-2 SPIKE PROTEIN WITH CPG OLIGODEOXYNUCLEOTIDES AND SQUALENE NANOPARTICLES MODULATES IMMUNOLOGICAL ASPECTS FOLLOWING INTRANASAL DELIVERY

Nasal spray vaccination is viewed as a promising strategy for inducing both mucosal and systemic protection against respiratory SARS-CoV-2 coronavirus.Toward this goal, a safe and efficacious mucosal adjuvant is necessary for the transportation of the antigen across the mucosal membrane and antigen recognition by the mucosal immune system to genera

Abstract Background Colorectal cancer (CRC) has become a significant global concern, presenting formidable challenges to healthcare systems and leading to substantial healthcare expenses.This study examines the projected prevalence and trends of CRC worldwide, encompassing 21 regions and 195 nations.Methods We employed an illness-death model (IDM)

Televisions The virus-induced signaling adaptor protein VISA (also known as MAVS, ISP-1, Cardif) is a critical adaptor protein in the innate immune response to RNA virus infection.Upon viral infection, VISA self-aggregates to form a sizeable prion-like complex and recruits downstream signal components for signal transduction.Here, we discover that

Forward osmosis (FO) has rarely been investigated as a treatment technology for industrial wastewaters.Within this study, common FO model equations were applied to simulate forward osmosis treatment of industrial wastewaters from the automobile industry.Three different models from literature were used and compared.Permeate and reverse solute flux m